Lots of people on this forum run mogas in their io-360. Considerations are compression, timing, fuel system compatibility, and ethanol content.
I've burned all kinds of mogas both with and without ethanol and the only problems I have seen is occasional low vapor pressure (use boost pump to avoid it) and fuel cap gasket swelling (changed them to Viton). I did get a service notice from Andair that they needed to do an upgrade on the fuel pump due to mogas incompatibility, but that was after I had already run a few hundred hours on mogas.
From time to time I use 100LL when mogas is not available, or very inconvenient.
Once flying, I can't perceive any difference. It might be interesting to throw all my data into a statistical analysis engine to see if it can detect any differences - perhaps Savvy or Flysto will add this someday.